Coenzyme Q10 (CoQ10)
- Effective dose
- 100–300 mg
- Evidence
- 3/5· Moderate
Last updated June 1, 2026
What it is
Coenzyme Q10 is a fat-soluble compound the body makes naturally and concentrates in energy-hungry tissues like the heart. It is essential for mitochondrial energy production and also acts as an antioxidant; levels can decline with age and are lowered by statin medications.
Benefits
The best-supported use is as adjunctive support in heart failure, where 100-300 mg/day improved functional capacity and outcomes in trials like Q-SYMBIO, and 100-200 mg/day is used to replenish statin-depleted stores. Evidence for relieving statin-associated muscle symptoms is inconsistent.
When to take it
Taken with a meal containing fat to improve absorption; splitting larger doses across meals improves blood levels.
Side effects
Generally well tolerated; mild digestive upset, nausea, or headache are occasionally reported. May modestly affect warfarin response.
Sources
Products containing Coenzyme Q10 (CoQ10)
No products in our database contain this ingredient yet.