Adapalene

What it is

Adapalene is a synthetic third-generation retinoid available over the counter (typically at 0.1%). It binds retinoic acid receptors in skin to normalize how cells lining the pores shed, which reduces the clogging and inflammation that drive acne.

Benefits

Reduces inflammatory and non-inflammatory acne lesions; the OTC 0.1% gel produces meaningful lesion reduction over about 12 weeks with efficacy comparable to prescription tretinoin 0.025% gel but better tolerability.

When to take it

Apply a thin layer at night to clean, dry skin; expect a purging/adjustment period over the first weeks. Always pair with broad-spectrum SPF in the morning.

Side effects

Early use commonly causes dryness, redness, peeling, and stinging (a mild retinoid dermatitis) that usually eases with continued use. It increases sun sensitivity.

Sources

• A review of the use of adapalene for the treatment of acne vulgaris (Clin Cosmet Investig Dermatol)
• Comparison of adapalene gel 0.1% and tretinoin gel 0.025% in acne vulgaris: multicenter trial (J Am Acad Dermatol)

Products containing Adapalene

No products in our database contain this ingredient yet.